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Ethical concerns over designer babies

The technique worked on three quarters of the 58 embryos it was tried on. It has the potential to revolutionise medicine and could lead to the eradication of inherited diseases such as cystic fibrosis and breast cancer.


*Campaigners warn breakthrough that removed faulty DNA could lead to creation of ‘superior’ children with genes modified to improve appearance or intelligence

A pioneering technique to ‘fix’ an embryo’s faulty Deoxy ribonucleic Acid (DNA)/genetic material was unveiled by scientists last week.In a world first, they used gene-editing to cut out DNA from a fertilised egg. The embryo then repaired itself, replacing the mutated material with healthy cells.

The technique worked on three quarters of the 58 embryos it was tried on. It has the potential to revolutionise medicine and could lead to the eradication of inherited diseases such as cystic fibrosis and breast cancer.

Campaigners warned however that it might also open the door to ‘superior designer babies’, with genes modified to improve physical appearance, strength or even intelligence.

“What concerns me most is that we will start making babies to order, and then expecting them to perform according to the way we have genetically designed them,” said Dr David King, of the campaign group Human Genetics Alert.Other experts said the research was remarkable and had taken gene-editing from “future fantasy to the world of possibility”.

Professor Simon Fishel, founder of Care Fertility, said: “This is exciting research that in time may herald a new approach for correcting embryos carrying devastating genetic disorders.

“Such technology would ensure that those families afflicted with such diseases no longer need worry about passing it down the family line.”The breakthrough was led by scientists from Oregon Health and Science University in Portland using the gene-editing tool Crispr-Cas9, which works like “molecular scissors”.

Embryos have been genetically edited before in China, in a series of small studies in 2015 which were met with widespread condemnation. It is illegal in the United Kingdom (U.K.) to use the technology on human embryos for anything other than research.In the new study, published in the Nature journal, the scientists successfully used Crispr-Cas9 to repair human embryos blighted by a single copy of a mutant gene, MYBPC3.

This gene causes the heart condition that famously caused 23-year-old footballer Fabrice Muamba to collapse on the pitch in 2012, his heart stopping for 78 minutes.Using standard In Vitro Fertilisation (IVF) techniques, the scientists first fertilised donor eggs with sperm containing the defective gene.

At the time of fertilisation, they applied the gene-editing tool that acts like a pair of precisely targeted genetic scissors.Once the defective elements of the gene had been snipped away, the embryo’s own cellular repair systems replaced them with healthy versions.

The researchers reported that 42 out of 58 of the embryos had been correctly fixed so that they no longer carried the heart failure mutation, which normally has a 50 per cent chance of being passed on and can lead to sudden death.

It occurs when the walls of the heart become thickened and stiff, making it more difficult for the organ to pump blood around the body.None of the embryos were permitted to develop beyond five days after conception. Had they lived, the babies would no longer develop the heart condition or pass it on to their own children. Fears have been raised that the gene-editing breakthrough unveiled in the United States could lead to designer babies.

That is because the nuclear DNA at the heart of a cell, which these scientists tweaked, also determines personal characteristics.This raises the prospect of genetically engineered ‘superheroes’ made to be more athletic or extra intelligent at the request of parents.

Scientists say that designer babies are a step closer following the breakthrough. But the researchers have edited only a single gene so far, using a technique which has still to be proven to work in babies rather than just embryos.Traits such as intelligence and strength are determined by multiple genes, meaning superhero children are not likely to happen soon.

However experts say that this idea is now no longer science fiction and some laboratories may feel pressure in future to try to tweak children’s eye colour and height.
Parents at risk of passing on genetic conditions to their children can only currently prevent it with embryo screening.

This means undergoing IVF, during which doctors cherry-pick embryos that do not appear to carry the mutated gene. But it is a genetic lottery and, devastatingly, all embryos could be carriers.The new research offers hope of cutting out more than 10,000 conditions involving genetic faults inherited from one parent.
*Culled from DailyMailUK Online

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